The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
第一作者:
Eun Jung,Park
第一单位:
Department of Pharmacology, School of Medicine Gyeongsang National University and Institute of Health Sciences, Jinju, Korea.
作者:
主题词
动物(Animals);消炎药(Anti-Inflammatory Agents);细胞系(Cell Line);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);基因表达调控(Gene Expression Regulation);HMGB1蛋白质(HMGB1 Protein);血红素加氧酶-1(Heme Oxygenase-1);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);NF-E2相关因子2(NF-E2-Related Factor 2);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);RNA干扰(RNA Interference);脓毒症(Sepsis);四氢异喹啉类(Tetrahydroisoquinolines)
DOI
10.1371/journal.pone.0076293
PMID
24098466
发布时间
2024-03-18
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PloS one
e76293页
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