Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process.
第一作者:
Huixian,Hong
第一单位:
Department of Hematology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
作者:
关键词
APCBMCBRCCMPCar2CtskFBSGAPDHGM-CSFGMPHSCIL-3IL-6Interleukin-3M-CSFMMP9MSCOsteoclast precursorOsteoclast progenitorOsteoclastogenesisPBSPERANKLRT-PCRSCFSEMTRAPallophycocyaninbone marrow cellsbone remodeling compartmentcarbonic anhydrase 2cathepsin Kcommon myeloid progenitorsfetal bovine serumglyceraldehyde 3-phosphate dehydrogenasegranulocyte/macrophage colony stimulating factorgranulocyte/macrophage progenitorshematopoietic stem cellsinterleukin 3interleukin 6matrix metalloproteinase 9mesenchymal stem cellsmonocyte/macrophage-colony stimulating factorphosphate-buffered buffersphycoerythrinreceptor activator of nuclear factor kappa B ligandreverse transcription-polymerase chain reactionscanning electron microscopystem cell factortartrate resistant acid phosphataseα-MEMα-minimal essential medium
主题词
动物(Animals);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);造血干细胞(Hematopoietic Stem Cells);白细胞介素3(Interleukin-3);巨噬细胞集落刺激因子(Macrophage Colony-Stimulating Factor);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);破骨细胞(Osteoclasts)
DOI
10.1016/j.bbrc.2013.09.098
PMID
24103757
发布时间
2021-10-21
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