Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics.

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作者： Eric J,de Waal ^[1] ; Maria,Desmidt ; Sven,Korte ; Marc,Niehoff ; Kevan,Chase ; Wayne,Arrowsmith ; Ann,Lampo

作者单位： Janssen Research and Development, a division of Janssen Pharmaceutica NV, Drug Safety Sciences, Department of Preclinical Project Development, Turnhoutseweg 30, 2340, Beerse, Belgium. ^[1]

关键词 EPS JNJ-37822681 antipsychotic dopamine D2 receptor antagonist extrapyramidal symptoms monkey prolactin rat

主题词动物(Animals);抗精神病药(Antipsychotic Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);人类(Humans);成束猴(Macaca fascicularis);男(雄)性(Male);乳腺, 动物(Mammary Glands, Animal);哌啶类(Piperidines);催乳素(Prolactin);哒嗪类(Pyridazines);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);精神分裂症(Schizophrenia);毒性试验(Toxicity Tests)

DOI 10.1002/jat.2916

PMID 24105799

发布时间 2014-08-01

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Journal of applied toxicology

2014年34卷9期

974-92页

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Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics.

Journal of applied toxicology

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Journal of applied toxicology

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Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and toxicokinetics.

Journal of applied toxicology

相似文献

Journal of applied toxicology

相关期刊

检索历史清除