Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling.
作者:
关键词
4-PBA4-phenylbutyrate4′,6-diamidino-2-phenylindoleAGEsBSADAPIDNDiabetic nephropathyERER stressGFPGRP78Green fluorescent proteinMOIPTECsPremature senescenceRAGESA-β-galSAHFTGTMadvanced glycation end-productsbovine serum albumindiabetic nephropathyendoplasmic reticulumglucose-regulated protein 78multiplicity of infectionp21proximal tubular epithelial cellsreceptor for advanced glycation end-productssenescence-associated heterochromatic focisenescence-associated-β-galactosidasethapsigargintunicamycin
主题词
老年人(Aged);动物(Animals);细胞, 培养的(Cells, Cultured);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);糖尿病肾病(Diabetic Nephropathies);上皮细胞(Epithelial Cells);反馈, 生理(Feedback, Physiological);人类(Humans);肾小管, 近端(Kidney Tubules, Proximal);小鼠(Mice);中年人(Middle Aged);受体, 免疫(Receptors, Immunologic);信号传导(Signal Transduction)
DOI
10.1016/j.cellsig.2013.10.002
PMID
24113348
发布时间
2022-03-11
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Cellular signalling
110-21页
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