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首页> Journal of neuroendocrinology> Lentivirus-mediated α-melanocyte-stimulating hormone overexpression in the hypothalamus decreases diet induced obesity in mice.

Lentivirus-mediated α-melanocyte-stimulating hormone overexpression in the hypothalamus decreases diet induced obesity in mice.

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作者： K,Eerola ^[1] ; W,Nordlund ^[2] ; S,Virtanen ^[3] ; A M,Dickens ^[1] ; M,Mattila ^[1] ; S T,Ruohonen ^[2] ; S C,Chua ^[1] ; S L,Wardlaw ^[4] ; M,Savontaus ^[2] ; E,Savontaus ^[5]

作者单位： Department of Pharmacology, Drug Development and Therapeutics, and Turku Center for Disease Modeling, University of Turku, Turku, Finland. ^[1] Turku Centre for Biotechnology, University of Turku, Turku, Finland. ^[2] FinPharma Doctoral Program, Drug Discovery Section, Turku, Finland. ^[3] Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland. ^[4] Medical Biochemistry and Genetics, University of Turku, Turku, Finland. ^[5] Albert Einstein College of Medicine, New York, NY, USA. ^[6] Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, USA. ^[7] Turku Heart Center, Turku University Hospital and University of Turku, Turku, Finland. ^[8] Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland. ^[9]

关键词 POMC mice neuropeptides obesity α-MSH

主题词动物(Animals);碱基序列(Base Sequence);DNA引物(DNA Primers);膳食(Diet);葡糖耐量试验(Glucose Tolerance Test);下丘脑(Hypothalamus);慢病毒属(Lentivirus);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肥胖症(Obesity);α促黑素(alpha-MSH)

DOI 10.1111/jne.12109

PMID 24118213

发布时间 2019-11-27

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Journal of neuroendocrinology

Journal of neuroendocrinology

2013年25卷12期

1298-1307页

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