PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.-论文-万方医学网

作者： William J,Israelsen ^[1] ; Talya L,Dayton ; Shawn M,Davidson ; Brian P,Fiske ; Aaron M,Hosios ; Gary,Bellinger ; Jie,Li ; Yimin,Yu ; Mika,Sasaki ; James W,Horner ; Laura N,Burga ; Jianxin,Xie ; Michael J,Jurczak ; Ronald A,DePinho ; Clary B,Clish ; Tyler,Jacks ; Richard G,Kibbey ; Gerburg M,Wulf ; Dolores,Di Vizio ; Gordon B,Mills ; Lewis C,Cantley ; Matthew G,Vander Heiden

作者单位： Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[1]

主题词动物(Animals);碱基序列(Base Sequence);乳腺肿瘤(Breast Neoplasms);外显子(Exons);女(雌)性(Female);基因缺失(Gene Deletion);基因敲除技术(Gene Knockout Techniques);人类(Humans);同工酶类(Isoenzymes);乳房肿瘤, 实验性(Mammary Neoplasms, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 分子(Models, Molecular);分子序列数据(Molecular Sequence Data);诱变(Mutagenesis);突变(Mutation);肿瘤转移(Neoplasm Metastasis);肿瘤移植(Neoplasm Transplantation);丙酮酸激酶(Pyruvate Kinase);RNA剪接(RNA Splicing)

DOI 10.1016/j.cell.2013.09.025

PMID 24120138

发布时间 2022-04-08

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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Cell

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Cell

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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

Cell

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Cell

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