换一批
换一批Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes.
作者：
关键词
5 (and 6)-carboxy-2′,7′-dichlorofluorescein5 (and 6)-carboxy-2′,7′-dichlorofluorescein diacetateALTANITAlpha-naphthylisothiocyanateBECsBEIBsepCDFCDFDACl(biliary)Cyp27a1Cyp7a1Cyp8b1DPDPEDrug-induced cholestasisELISAGC–MSHBSSHank's balanced salt solutionIPRLsLC–MS/MSLDHMrpNtcpOatpPLS-DASCRHSandwich-cultured hepatocytesTransporterVPA[D-Pen(2,5)]-enkephalinalanine transaminasealpha-naphthylisothiocyanatebile salt export pumpbiliary clearancebiliary epithelial cellsbiliary excretion indexcholesterol 7α-hydroxylased8-TCAdeuterium-labeled sodium taurocholateenzyme-linked immunosorbent assaygas chromatography–mass spectrometryisolated perfused rat liverslactate dehydrogenaseliquid chromatography–mass spectrometry tandem mass spectrometrymultidrug resistance-associated proteinorganic anion transporting polypeptidepartial least squares discriminant analysissandwich-cultured rat hepatocytessodium/taurocholate cotransporting polypeptidesterol 12α-hydroxylasesterol 27-hydroxylasevalproic acid
主题词
异硫氰酸1-萘酯(1-Naphthylisothiocyanate);ATP结合匣式转运子(ATP-Binding Cassette Transporters);动物(Animals);胆汁酸类和盐类(Bile Acids and Salts);生物转运(Biological Transport);细胞, 培养的(Cells, Cultured);肝细胞(Hepatocytes);男(雄)性(Male);代谢组(Metabolome);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)
DOI
10.1016/j.toxlet.2013.09.019
PMID
24120425
发布时间
2017-12-13
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Toxicology letters
93-100页
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