High throughput quantification of capsular polysaccharides for multivalent vaccines using precipitation with a cationic surfactant.
第一作者:
Aaron,Noyes
第一单位:
The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK; Purification Process Development, Pfizer, 1 Burtt Road, Andover, MA 01810, USA. Electronic address: Aaron.Noyes@pfizer.com.
作者:
关键词
Anionic capsular polysaccharidesCMCCPSHTPDHbHexadecyltrimethylammonium bromideHigh throughput process developmentIMn CMn YRSDSugar quantitationTiterVaccinecapsular polysaccharidecritical micelle concentrationhexadecyltrimethylammonium bromidehigh throughput process developmentionic strengthmeningococcal serotype C capsular polysaccharidemeningococcal serotype Y capsular polysacchariderelative standard deviation
医学主题词
细菌菌苗(Bacterial Vaccines);阳离子(Cations);西曲铵化合物(Cetrimonium Compounds);化学沉淀(Chemical Precipitation);高通量筛选分析(High-Throughput Screening Assays);多糖类(Polysaccharides);分光光度法(Spectrophotometry);表面活性剂(Surface-Active Agents)
DOI
10.1016/j.vaccine.2013.09.075
PMID
24120674
发布时间
2019-12-10
- 浏览104
Vaccine
5659-65页
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