Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.

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作者： John O,Hwabejire ^[1] ; Jennifer,Lu ; Baoling,Liu ; Yongqing,Li ; Ihab,Halaweish ; Hasan B,Alam

作者单位： Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts. ^[1]

关键词 Dose optimization Hemorrhagic shock Histone deacetylase inhibitors Valproic acid

主题词乙酰化作用(Acetylation);动物(Animals);剂量效应关系, 药物(Dose-Response Relationship, Drug);糖原合成酶激酶3(Glycogen Synthase Kinase 3);组蛋白类(Histones);男(雄)性(Male);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);休克, 出血性(Shock, Hemorrhagic);丙戊酸(Valproic Acid)

DOI 10.1016/j.jss.2013.09.016

PMID 24135375

发布时间 2021-10-21

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The Journal of surgical research

2014年186卷1期

363-70页

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Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.

The Journal of surgical research

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Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.

The Journal of surgical research

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The Journal of surgical research

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