Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.
作者:
关键词
BafA1Bafilomycin A1BoNT/XBotulinum neurotoxinC-terminal domain of the H(C)-fragmentC-terminal half of HCCGNsFBSH(C)H(CC)H(CN)H(N)HCLCMEMMPNN-terminal domain of the H(C)-fragmentN-terminal half of HCPBSPC12Phrenic nerve hemidiaphragm toxicity testSNAP-25SNAREsSV2TMTranslocationVAMP-2WTa pheochromocytoma cell linebafilomycin A1botulinum neurotoxin/serotype Xcerebellar granule neuronsfoetal bovine serumheavy chainlight chainmice phrenic nerveminimum essential mediumpH sensorphosphate buffered salinesoluble N-ethyl maleimide sensitive factor attachment protein receptorssynaptic vesicle (glyco-)protein 2synaptosomal-associated protein of 25kDatriple mutantvesicle associated membrane protein 2wild-type
主题词
动物(Animals);天冬氨酸(Aspartic Acid);肉毒毒素类(Botulinum Toxins);肉毒杆菌毒素类, A型(Botulinum Toxins, Type A);催化域(Catalytic Domain);细胞膜(Cell Membrane);细胞, 培养的(Cells, Cultured);胞质溶胶(Cytosol);谷氨酸(Glutamic Acid);氢离子浓度(Hydrogen-Ion Concentration);小鼠(Mice);突变(Mutation);神经元(Neurons);神经毒素类(Neurotoxins);蛋白质转运(Protein Transport);质子(Protons)
DOI
10.1016/j.febslet.2013.10.010
PMID
24157364
发布时间
2015-11-19
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FEBS letters
3831-6页
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