换一批Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-κB and COX-2.
第一作者：
Periasamy,Ramyaa
第一单位：
Animal Tissue Culture and Molecular Genetics Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore, India.
作者：
关键词
2,7-dichlorodihydrofluorescein diacetate2,7-dichlorofluorescein3,30-di-hexyloxacarbocyanine iodide3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4,4-diamidino-2-phenylindoleANOVAAO/EBAREAcridine orange/ethidium bromideAnalysis of varianceAntioxidant responsive elementCATCBMNCCCPCOX-2Carbonyl cyanide m-chlorophenylhydrazoneCatalaseCyclooxygenase-2Cytokinesis block micronucleus assayDABDAPIDCFDCF-DADMEMDNA damageDTTDiOC6DiaminobenzidineDithiothreitolDulbecco's modified Eagle's mediumEDTAEthylenediamine tetraacetic acidFBSFetal bovine serumGPxGSHGSTGlutathioneGlutathione S transferaseGlutathione peroxidaseIC20Inducible nitric oxide synthaseInflammationInhibitory concentration 20Intracellular calcium levelLDHLPOLPSLactate dehydrogenaseLipid peroxidationLipopolysaccharideMNMTTMicronucleusNF-κBNONitric oxideNrf-2Nuclear factor E2 p45-related factor 2Nuclear factor-kappa BOPTOTAOchratoxinOrtho-phthalaldehydeOxidative stressPCCPMSFPhenyl methyl sulfonyl fluorideProtein carbonyl contentQuercetinROSReactive oxygen speciesSODSuperoxide dismutase[Ca(2+)](i)iNOS
主题词
抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);钙(Calcium);钙通道阻滞药(Calcium Channel Blockers);细胞增殖(Cell Proliferation);环氧化酶2(Cyclooxygenase 2);胞质分裂(Cytokinesis);荧光抗体技术(Fluorescent Antibody Technique);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);谷胱甘肽(Glutathione);Hep G2细胞(Hep G2 Cells);人类(Humans);脂质过氧化作用(Lipid Peroxidation);微核试验(Micronucleus Tests);NF-E2相关因子2(NF-E2-Related Factor 2);NF-κB(NF-kappa B);亚硝酸盐类(Nitrites);赫曲霉毒素类(Ochratoxins);氧化还原(Oxidation-Reduction);氧化性应激(Oxidative Stress);蛋白质羟基化(Protein Carbonylation);槲皮素(Quercetin);活性氧(Reactive Oxygen Species)
DOI
10.1016/j.bbagen.2013.10.024
PMID
24161694
发布时间
2022-03-09
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