Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

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作者： Muhammad M,Mohiuddin ^[1] ; Avneesh K,Singh ; Philip C,Corcoran ; Robert F,Hoyt ; Marvin L,Thomas ; Billeta G T,Lewis ; Michael,Eckhaus ; Nicole L,Dabkowski ; Aaron J,Belli ; Keith A,Reimann ; David,Ayares ; Keith A,Horvath

作者单位： Cardiothoracic Surgery Research Laboratory, NHLBI, NIH, Bethesda, MD, USA. ^[1]

关键词 2C10R4 Anti-CD40 antibody CD46 Gal KO pigs cardiac xenograft non-Gal antibodies xenotransplantation

主题词动物(Animals);动物, 基因修饰(Animals, Genetically Modified);抗体(Antibodies);抗体生成(Antibody Formation);B-淋巴细胞(B-Lymphocytes);CD40配体(CD40 Ligand);移植物排斥(Graft Rejection);移植物存活(Graft Survival);免疫抑制剂(Immunosuppressive Agents);狒狒属(Papio);野猪(Sus scrofa);猪(Swine);移植, 异种(Transplantation, Heterologous)

DOI 10.1111/xen.12066

PMID 24164510

发布时间 2024-06-03

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Xenotransplantation

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Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

Xenotransplantation

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Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

Xenotransplantation

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Xenotransplantation

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