5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze.
第一作者:
Margherita M,Karabeg
第一单位:
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany ; Division of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
作者:
医学主题词
动物(Animals);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);皮质酮(Corticosterone);基因表达调控(Gene Expression Regulation);海马(Hippocampus);Ki-67抗原(Ki-67 Antigen);男(雄)性(Male);迷宫学习(Maze Learning);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);神经组织蛋白质类(Nerve Tissue Proteins);神经元可塑性(Neuronal Plasticity);血清素质膜转运蛋白质类(Serotonin Plasma Membrane Transport Proteins);应激, 生理学(Stress, Physiological)
DOI
10.1371/journal.pone.0078238
PMID
24167611
发布时间
2021-10-21
- 浏览18
PloS one
e78238页
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