Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals.

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作者： Greta,Carmona-Antoñanzas ^[1] ; Douglas R,Tocher ; Laura,Martinez-Rubio ; Michael J,Leaver

作者单位： School of Natural Sciences, University of Stirling, Institute of Aquaculture, Stirling FK9 4LA, UK. Electronic address: g.e.carmonaantonanzas@stir.ac.uk. ^[1]

关键词 3-hydroxy-3-methyl-glutaryl-CoA reductase ABCA1 ACOX ARA ATP-binding cassette transporter 1 Atlantic salmon CYP7α1 DHA DMEM DNA complementary to RNA Dulbecco's modified eagle medium EDTA ELF-1α ELOVL EPA ER FA FADS FAS FBS FHM FO Fatty acid Gene expression HMG-CoAR LBD LC-PUFA LO LXR LXR response element LXRE Lipid ORF PBS PPAR PPAR response element PPRE PUFA Pyloric caeca RE RO RXR SCD SHK-1 SO SRE SREBP TF Transcription factor UAS VO aa acyl-CoA oxidase amino acid(s)arachidonic acid base pair(s)bp cDNA cholesterol 7alpha-hydroxylase docosahexaenoic acid eicosapentaenoic acid elongase of very long-chain fatty acids elongation factor 1 alpha endoplasmic reticulum ethylenediaminetetraacetic acid fathead minnow epithelial cells fatty acid fatty acid desaturase fatty acid synthase fetal bovine serum fish oil ligand binding domain linseed oil liver X receptor long-chain polyunsaturated fatty acids mRNA messenger RNA open reading frame peroxisome proliferator-activated receptors phosphate buffer saline polyunsaturated fatty acids qPCR quantitative RT-PCR rapeseed oil response element retinoid X receptor salmon head kidney cells serum response element soybean oil stearoyl CoA desaturase sterol regulatory element binding proteins transcription factor upstream activation sequence vegetable oil

主题词动物(Animals);胆固醇(Cholesterol);膳食脂肪类(Dietary Fats);脂肪酸类(Fatty Acids);女(雌)性(Female);鱼蛋白质类(Fish Proteins);基因调控网络(Gene Regulatory Networks);脂类代谢(Lipid Metabolism);男(雄)性(Male);哺乳动物(Mammals);模型, 生物学(Models, Biological);鲑(Salmon);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1);转录因子(Transcription Factors);转录, 遗传(Transcription, Genetic)

DOI 10.1016/j.gene.2013.10.040

PMID 24177230

发布时间 2013-11-25

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Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals.

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Conservation of lipid metabolic gene transcriptional regulatory networks in fish and mammals.

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