Efficient siRNA delivery and tumor accumulation mediated by ionically cross-linked folic acid-poly(ethylene glycol)-chitosan oligosaccharide lactate nanoparticles: for the potential targeted ovarian cancer gene therapy.
第一作者:
Tony Shing Chau,Li
第一单位:
Department of Biochemistry, Kochi Medical School, Kochi University, Oko-Cho, Nankoku, Kochi 783-8505, Japan.
作者:
关键词
ANOVABCACOLCVChitosanDCCDClDEPCDLSDMEMDulbecco’s modified eagle’s mediumECLEDCEPREtBrFAFA–PEG–COLFBSFT-IRFolic acidFourier transformed infrared spectroscopyHIF-1αHRPMALDI-TOF-MSMWCON-(3-dimethylaminopropyl)-N-ethylcarbodiimideN-hydroxysuccinimideNH(2)–PEG–COOHNHSNIRFNPsNTCNanoparticlesOvarian cancerPDIPVDFRBCsRGD peptideRT-qPCRTBETBS-TTPPTargetingTris-buffered saline with TweenTris/borate/EDTAanalysis of variancearginine–glycine–aspartic acid peptidebicinchoninic acidcentipoisechitosan oligosaccharide lactatecoefficient of variationcpsdeuterium chloridedicyclohexylcarbodiimidediethyl pyrocarbonatedynamic light scatteringenhanced chemiluminescenceenhanced permeability and retention effectethidium bromidefetal bovine serumfolic acidfolic acid–poly(ethylene glycol)–chitosan oligosaccharide lactatehorseradish peroxidisehypoxic inducible factor-1 alphamatrix-assisted laser desorption/ionization-time of flight mass spectrometrymolecular weight cut offnanoparticlesnear-infrared fluorescenceno template controlpolydispersity indexpolyvinylidene fluoridereal-time quantitative polymerase chain reactionred blood cellssiRNAtripolyphosphateα-aminopropyl-ω-carboxypentyloxy-polyxyethylene?hydrochloride
医学主题词
动物(Animals);羰花青(Carbocyanines);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);壳聚糖(Chitosan);女(雌)性(Female);荧光染料(Fluorescent Dyes);叶酸(Folic Acid);基因敲低技术(Gene Knockdown Techniques);溶血(Hemolysis);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);小鼠(Mice);小鼠, 裸(Mice, Nude);纳米粒子(Nanoparticles);卵巢肿瘤(Ovarian Neoplasms);聚乙烯二醇类(Polyethylene Glycols);RNA, 小分子干扰(RNA, Small Interfering)
DOI
10.1016/j.ejps.2013.10.011
PMID
24178005
发布时间
2018-12-03
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