换一批Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.
第一作者：
Anna Francina,Jackson
第一单位：
Environmental Health Science and Research Bureau, Health Canada, Ottawa K1A 0K9, Canada; Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa K1S 5B6, Canada. Electronic address: Francina.Jackson@hc-sc.gc.ca.
作者：
关键词
AP-1APAPASK1AcetaminophenActivator protein 1Apoptosis signaling kinaseBDABMDBMDLBenchmark doseBody weightBrdUBromodeoxyuridineCTCarbon tetrachlorideCyp2E1Cytochrome P450 2E1ERKEtOHEthanolExtracellular signal-regulated kinaseFuranGOGSHGene expressionGene ontologyGlutathioneHCAHCCHepatocellular adenomaHepatocellular carcinomaIARCIPAIRISIndirect-acting genotoxic carcinogenIngenuity Pathway AnalysisIntegrated Risk Information SystemInternational Agency for Research on CancerJNK1Jun proto-oncogeneLower confidence limit of benchmark doseMAPKMOAMPTMitochondrial permeability transitionMitogen-activated protein kinaseMode of actionNF-κBNTPNational Toxicology ProgramNon-genotoxic carcinogenNrf2/NFE2L2Nuclear factor (erythroid-derived 2)-like 2Nuclear factor kappa BPHPODPartial hepatectomyPoint of departureROSReactive oxygen speciesRisk assessmentSAPKStress-activated protein kinaseTNFTNF receptor 1TNFR1ToxicogenomicsTumor necrosis factorbwc-Junc-Jun NH2-terminal kinase 1cis-2-butene-1,4-dial
医学主题词
动物(Animals);致癌物(Carcinogens);剂量效应关系, 药物(Dose-Response Relationship, Drug);女(雌)性(Female);呋喃类(Furans);基因表达谱(Gene Expression Profiling);肝细胞(Hepatocytes);肝(Liver);小鼠(Mice);危险性评估(Risk Assessment)
DOI
10.1016/j.taap.2013.10.019
PMID
24183702
发布时间
2013-12-20
- 浏览114
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
