Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents.

导出 LinkOut

翻译打印收藏纠错

作者： Hao,Shao ^[1] ; Shenhua,Shi ; David W,Foley ; Frankie,Lam ; Abdullah Y,Abbas ; Xiangrui,Liu ; Shiliang,Huang ; Xiangrui,Jiang ; Nadiah,Baharin ; Peter M,Fischer ; Shudong,Wang

作者单位： School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK. ^[1]

关键词 Anti-cancer drug discovery CDK9 inhibitors Inhibitor design Mcl-1 anti-apoptotic proteins RNA polymerase II

主题词抗肿瘤药(Antineoplastic Agents);细胞增殖(Cell Proliferation);细胞周期蛋白质依赖激酶类(Cyclin-Dependent Kinases);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);HCT116细胞(HCT116 Cells);人类(Humans);模型, 分子(Models, Molecular);分子结构(Molecular Structure);蛋白激酶抑制剂(Protein Kinase Inhibitors);嘧啶类(Pyrimidines);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2013.08.052

PMID 24185375

发布时间 2013-12-09

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览27

European journal of medicinal chemistry

2013年70卷

447-55页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

检索历史清除