换一批
换一批Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity.
第一作者：
Hideki,Hara
第一单位：
1] Department of Microbiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. [2].
作者：
主题词
动物(Animals);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);骨髓细胞(Bone Marrow Cells);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);载体蛋白质类(Carrier Proteins);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);细胞, 培养的(Cells, Cultured);细胞支架蛋白质类(Cytoskeletal Proteins);DNA结合蛋白质类(DNA-Binding Proteins);树突细胞(Dendritic Cells);女(雌)性(Female);HEK293细胞(HEK293 Cells);人类(Humans);免疫印迹法(Immunoblotting);炎性体(Inflammasomes);白细胞介素18(Interleukin-18);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);尼日利亚菌素(Nigericin);核蛋白质类(Nuclear Proteins);磷酰化(Phosphorylation);蛋白酪氨酸激酶类(Protein-Tyrosine Kinases);RNA干扰(RNA Interference);酪氨酸(Tyrosine)
DOI
10.1038/ni.2749
PMID
24185614
发布时间
2022-01-29
- 浏览2
Nature immunology
1247-55页
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