换一批
换一批Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.
作者：
关键词
3V, third ventricleACTH, adrenocorticotropic hormoneAP, adenopituitaryARC, arcuate nucleus of the hypothalamusAUC, area under the curveAcp2, acid phosphatase 2, lysosomalAgRP, agouti-related proteinAgo2, Argonaute 2CART, cocaine and amphetamine-related transcriptCNS, central nervous systemCRH, corticotropin releasing hormoneCrhr1, corticotrophin releasing hormone receptor 1Cx, CortexDIO, diet-induced obesityDicerFa, Fascicular zoneGFP, green fluorescent proteinGapdh, Glyceraldehyde 3-phosphate dehydrogenaseGh, growth hormoneGl, Glomerular zoneHprt, Hypoxanthine guanine phosphoribosyl transferaseHypothalamusIL, intermediate lobeIP, intraperitonealLH, lateral hypothalamusMC3R, melanocortin receptor 3MC4R, melanocortin receptor 4MZ, Marginal ZoneMe, MedulaMyc, myelocytomatosis oncogeneNP, neurohypophysisNPY, neuropeptide YNS, not significantNaglu, alpha-N-acetylglucosaminidaseNeurodegenerationNhlrc1, NHL repeat containing 1Ntrk2, Neurotrophic tyrosine kinase, receptor, type 2ObesityPOMCPOMC, pro-opiomelanocortinPOMCDicerKO, mice lacking Dicer in POMC-expressing cellsPVN, paraventricular nucleusPark2, ParkinPit1, pituitary-specific transcription factor 1Re, Reticular zoneRps24, ribosomal protein S24Rps9, ribosomal protein S9Tpit, T box transcription factorTshβ, thyroid-stimulating hormone β chainUD, undetectableUPS, ubiquitin proteosome systemUTR, untranslated regionVMH, ventromedial hypothalamusYFP, yellow fluorescent protein.miRISC, miRNA-induced silencing complexesmiRNA, microRNAmicroRNAqPCR, quantitative real-time PCR
DOI
10.1016/j.molmet.2012.10.001
PMID
24199146
发布时间
2021-10-21
- 浏览98
Molecular metabolism
2012年2卷2期
74-85页
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