The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
作者:
主题词
动物(Animals);细胞分化(Cell Differentiation);糖尿病, 1型(Diabetes Mellitus, Type 1);疾病模型, 动物(Disease Models, Animal);基因表达调控(Gene Expression Regulation);胰高血糖素(Glucagon);胰高血糖素分泌细胞(Glucagon-Secreting Cells);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);胰岛素分泌细胞(Insulin-Secreting Cells);胰岛(Islets of Langerhans);小鼠, 转基因(Mice, Transgenic);成对盒转录因子类(Paired Box Transcription Factors);转录因子(Transcription Factors)
DOI
10.1371/journal.pgen.1003934
PMID
24204325
发布时间
2022-03-30
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PLoS genetics
e1003934页
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