换一批Protein engineering and the use of molecular modeling and simulation: the case of heterodimeric Fc engineering.
第一单位：
Zymeworks Inc., 540-1385 West 8th Avenue, Vancouver, British Columbia V6H 3V9, Canada.
作者：
关键词
Antibody engineeringBispecific antibodyCCSDCIComputational protein engineeringFc engineeringHeterodimeric antibodyHphobicKBPKiHLJLennard-Jones contributionsMDRDFRMSDRMSFSASATmcharge inversionclose contact surface density (Δσ(tot))elecelectrostatic contributionsh-bondhydrogen bondhydrophobicknob in holeknowledge based potentialmolecular dynamicsradial distribution functionroot mean squared deviationroot mean squared fluctuationsolvent exposed surface areathermal melting temperaturevan der Waals interactionvdW
医学主题词
氨基酸取代(Amino Acid Substitution);动物(Animals);抗体特异性(Antibody Specificity);结合部位(Binding Sites);人类(Humans);氢键合(Hydrogen Bonding);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);分子动力学模拟(Molecular Dynamics Simulation);蛋白质工程(Protein Engineering);蛋白质稳定性(Protein Stability);蛋白质结构, 二级(Protein Structure, Secondary)
DOI
10.1016/j.ymeth.2013.10.016
PMID
24211748
发布时间
2014-01-08
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