换一批
换一批Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression.
第一作者：
A H V,Remels
第一单位：
NUTRIM School for Nutrition, Toxicology & Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre +, Maastricht, the Netherlands. Electronic address: a.remels@maastrichtuniversity.nl.
作者：
关键词
3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide50S ribosomal subunit protein L1560S ribosomal protein L13aACTBALAS1ATPAdAdenosine triphosphateAdenoviralB2MBMIBeta Cytoskeletal ActinBody mass indexCACOPDCOXIVCSChronic obstructive pulmonary diseaseCitrate synthaseClassical NF-κBConstitutively activeCytochrome c oxidase 4DMEMDelta-aminolevulinate synthase 1Dulbecco's Modified Eagle MediumFEV1FVCForced expiratory volume in one secondForced vital capacityGAPDHGUSBGapdh, Glyceraldehyde-3-phosphate dehydrogenaseGfpGlucuronidase, bètaGreen fluorescent proteinHADHBSSHCBPHMBSHPRTHank's Balanced Salt solutionHprt, Hypoxanthine phosphoribosyltransferase 1Human carnitine-palmitoyl transferase BHydroxymethylbilane SynthaseIKK-αIcam-1Ikk-α, IκB kinase alphaIkk-βIl-1βIntra-cellular adhesion molecule 1IκB kinase betaIκBαMlcMyhcMyosin heavy chainMyosin light chainNF-κBNSNot significantNrfNuclear factor kappa BNuclear respiratory factorOXPHENOxidative metabolismOxidative phenotypeOxidative phosphorylationOxphosPBSPGC-1PPARPPIAPgc-1, Peroxisome proliferator-activated receptor gamma co-activator 1Phosphate-buffered salinePpar, Peroxisome proliferator-activated receptorRPL13ARPLOSDSEMSRSkeletal muscleStandard deviationStandard equality of the meanSuper repressorTFAMTNF-αTfam, Mitochondrial transcription factor ATnf-α, Tumour necrosis factor alphaUBCUbiquitin CWTWild-typeYWHAZinterleukin 1βnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alphapeptidylprolyl isomerase A (cyclophilin A)β-hydroxyacyl-CoA dehydrogenaseβ2m, Beta 2 microglobulin
主题词
老年人(Aged);动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞系(Cell Line);女(雌)性(Female);基因表达调控(Gene Expression Regulation);人类(Humans);I-κB激酶(I-kappa B Kinase);男(雄)性(Male);小鼠(Mice);中年人(Middle Aged);肌纤维, 骨骼(Muscle Fibers, Skeletal);肌, 骨骼(Muscle, Skeletal);NF-κB(NF-kappa B);氧化还原(Oxidation-Reduction);表型(Phenotype);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);四头肌(Quadriceps Muscle);RNA干扰(RNA Interference);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.bbadis.2013.11.001
PMID
24215713
发布时间
2016-11-26
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