Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.

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作者： Aldo,Germani ^[1] ; Antonio,Matrone ^[1] ; Valentina,Grossi ^[2] ; Alessia,Peserico ^[1] ; Paola,Sanese ^[1] ; Micaela,Liuzzi ^[3] ; Rocco,Palermo ^[4] ; Stefania,Murzilli ^[5] ; Antonio Francesco,Campese ^[4] ; Giuseppe,Ingravallo ^[3] ; Gianluca,Canettieri ^[4] ; Tugsan,Tezil ^[6] ; Cristiano,Simone ^[7]

作者单位： Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy. ^[1] Cancer Genetics Laboratory, IRCCS S. de Bellis, 70013 Castellana Grotte, Italy. ^[2] Division of Pathological Anatomy, DETO, University of Bari, 70124 Bari, Italy. ^[3] Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy. ^[4] Animal Care Facility, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy. ^[5] Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy. Electronic address: teziltugsan@sabanciuniv.edu. ^[6] Laboratory of Signal-Dependent Transcription, Department of Translational Pharmacology (DTP), Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Ch), Italy; Division of Medical Genetics, DIMO, University of Bari, 70124 Bari, Italy. Electronic address: cristiano.simone@uniba.it. ^[7]

关键词 Cell death Chemoresistance Colorectal cancer Dual therapy p38 MAPK