Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.-论文-万方医学网

作者： David J,Lloyd ^[1] ; David J,St Jean ^[2] ; Robert J M,Kurzeja ^[2] ; Robert C,Wahl ^[2] ; Klaus,Michelsen ^[2] ; Rod,Cupples ^[1] ; Michelle,Chen ^[1] ; John,Wu ^[1] ; Glenn,Sivits ^[1] ; Joan,Helmering ^[1] ; Renée,Komorowski ^[1] ; Kate S,Ashton ^[2] ; Lewis D,Pennington ^[2] ; Christopher,Fotsch ^[2] ; Mukta,Vazir ^[2] ; Kui,Chen ^[2] ; Samer,Chmait ^[2] ; Jiandong,Zhang ^[2] ; Longbin,Liu ^[2] ; Mark H,Norman ^[2] ; Kristin L,Andrews ^[2] ; Michael D,Bartberger ^[2] ; Gwyneth,Van ^[3] ; Elizabeth J,Galbreath ^[3] ; Steven L,Vonderfecht ^[3] ; Minghan,Wang ^[1] ; Steven R,Jordan ^[2] ; Murielle M,Véniant ^[1] ; Clarence,Hale ^[1]

作者单位： Department of Metabolic Disorders, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. ^[1] Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. ^[2] Department of Comparative Biology & Safety Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. ^[3]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);血糖(Blood Glucose);载体蛋白质类(Carrier Proteins);细胞核(Cell Nucleus);结晶学, X线(Crystallography, X-Ray);糖尿病, 2型(Diabetes Mellitus, Type 2);疾病模型, 动物(Disease Models, Animal);肝细胞(Hepatocytes);人类(Humans);高血糖症(Hyperglycemia);降血糖药(Hypoglycemic Agents);肝(Liver);男(雄)性(Male);模型, 分子(Models, Molecular);器官特异性(Organ Specificity);磷酰化(Phosphorylation);哌嗪类(Piperazines);蛋白质结合(Protein Binding);蛋白质转运(Protein Transport);大鼠(Rats);大鼠, Wistar(Rats, Wistar);磺胺类(Sulfonamides)

DOI 10.1038/nature12724

PMID 24226772

发布时间 2022-03-21

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.

Nature

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.

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