换一批
换一批Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration.
第一作者：
Bettina,Laursen
第一单位：
H. Lundbeck A/S, Synaptic Transmission 1, Ottiliavej 9, 2500 Valby, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: xbc@lundbeck.com.
作者：
关键词
AChADAPPAcetylcholineAlzheimer's diseaseAlzheimer’s diseaseAβBFCDChATCognitive deficitHPLCM2RMu p75-saporinPS1PS2SAPT-CATT-maze continuous alternation task.Tg2576acetylcholineamyloid betaamyloid precursor proteinbasal forebrain cholinergic degenerationcholine acetyltransferasehigh performance liquid chromatographyicvintracerebroventricularmu p75-saporinmuscarinic acetylcholine receptor 2presenilin 1presenilin 2wild type littermatewt
主题词
乙酰胆碱(Acetylcholine);阿尔茨海默病(Alzheimer Disease);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);胆碱O-乙酰转移酶(Choline O-Acetyltransferase);疾病模型, 动物(Disease Models, Animal);海马(Hippocampus);人类(Humans);免疫毒素类(Immunotoxins);迷宫学习(Maze Learning);记忆障碍(Memory Disorders);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经变性(Nerve Degeneration);早老素1(Presenilin-1);前脑(Prosencephalon);核糖体失活蛋白质类, 1型(Ribosome Inactivating Proteins, Type 1)
DOI
10.1016/j.brainres.2013.10.055
PMID
24231553
发布时间
2022-03-21
- 浏览16
Brain research
253-62页
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