Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease.

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作者： Matthew A,Lalli ^[1] ; Hannah C,Cox ^[2] ; Mary L,Arcila ^[1] ; Liliana,Cadavid ^[3] ; Sonia,Moreno ^[3] ; Gloria,Garcia ^[3] ; Lucia,Madrigal ^[3] ; Eric M,Reiman ^[4] ; Mauricio,Arcos-Burgos ^[5] ; Gabriel,Bedoya ^[6] ; Mary E,Brunkow ^[2] ; Gustavo,Glusman ^[2] ; Jared C,Roach ^[2] ; Leroy,Hood ^[2] ; Kenneth S,Kosik ^[7] ; Francisco,Lopera ^[3]

作者单位： Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, USA. ^[1] Institute for Systems Biology, Seattle, WA, USA. ^[2] Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia. ^[3] Banner Alzheimer's Institute, Phoenix, AZ, USA. ^[4] Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia; Translational Genomics Group, Genome Biology Department, John Curtin School of Medical Research, ANU College of Medicine, Biology and Environment, The Australian National University, Canberra, ACT, Australia. ^[5] Grupo de Genetica Molecular (GENMOL), Universidad de Antioquia, Medellín, Colombia. ^[6] Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, USA. Electronic address: kosik@lifesci.ucsb.edu. ^[7]

关键词 Alzheimer’s disease PSEN1 population genetics whole-genome sequencing