Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs.
作者:
关键词
Actin cytoskeletonCell contractilityChondrocyteERKGAGILKMAPKMEKPI3KPI3K, PKC, MAPK, ILKPKCRe-differentiationStaurosporineextracellular signaling regulated kinaseglycosaminoglycanintegrin-linked kinasemitogen-activated protein kinasemitogen-activated protein kinase kinasephosphoinositide-3-kinaseprotein kinase C
主题词
辅肌动蛋白(Actinin);动物(Animals);软骨(Cartilage);牛(Cattle);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);软骨细胞(Chondrocytes);细胞松弛素D(Cytochalasin D);细胞骨架(Cytoskeleton);细胞外信号调节MAP激酶类(Extracellular Signal-Regulated MAP Kinases);成纤维细胞(Fibroblasts);基因表达调控(Gene Expression Regulation);肌球蛋白类(Myosins);表型(Phenotype);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);蛋白激酶C(Protein Kinase C);星状孢子素(Staurosporine)
DOI
10.1016/j.yexcr.2013.11.004
PMID
24246223
发布时间
2013-12-24
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