换一批
换一批Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab.
第一作者：
Elaine,Mai
第一单位：
Corresponding Author: Judy C. Young, Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, MS98, South San Francisco, CA 94080. jyoung@gene.com.
作者：
主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞系, 肿瘤(Cell Line, Tumor);剂量效应关系, 药物(Dose-Response Relationship, Drug);胞吞作用(Endocytosis);流式细胞术(Flow Cytometry);肝细胞生长因子(Hepatocyte Growth Factor);人类(Humans);免疫测定(Immunoassay);成束猴(Macaca fascicularis);小鼠, 近交C3H(Mice, Inbred C3H);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);小鼠, 转基因(Mice, Transgenic);显微镜检查, 荧光(Microscopy, Fluorescence);肿瘤(Neoplasms);原癌基因蛋白质c-met(Proto-Oncogene Proteins c-met);RNA干扰(RNA Interference);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1535-7163.MCT-13-0494
PMID
24258345
发布时间
2020-09-30
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