Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

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作者： Takumi,Satoh ^[1] ; Scott R,McKercher ^[2] ; Stuart A,Lipton ^[3]

作者单位： Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA; Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate 020-8551, Japan. Electronic address: tsatoh@sanfordburnham.org. ^[1] Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA. ^[2] Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, USA. Electronic address: slipton@sanfordburnham.org. ^[3]

关键词 ABCC ARE ATP-binding cassette, subfamily C Antioxidant-response element CA CS Carnosol DA DMF DOX Dimethyl fumarate (also known as BG-12)Dopamine Doxorubicin (also known as adriamycin)EP Electrophile Electrophilic counterattack GCLC GCLM GSH GST Glutamyl cysteine ligase catalytic subunit Glutamyl cysteine ligase modifier subunit Glutathione Glutathione-S-transferase H(2)O(2)HO-1 HSE HSF-1 HSP Heat-shock factor-1 Heat-shock protein Hemeoxygenase-1 Hydrogen peroxide Keap1 Kelch-like ECH-associated protein 1 MS Multiplesclerosis NADPH quinone oxidoreductase 1 NEPP NGF NQO1 Na+-independent cystine-glutamate exchanger Nerve growth factor Neurite outgrowth-promoting prostaglandin Nrf2 Nuclear factor (erythroid-derived 2)-like 2 PAT PD PED Parkinson's disease Pathologically activated therapeutic Pro-electrophilic drug RNS ROS Reactive nitrogen species Reactive oxygen species STR Strongylophorin TBHQ Tert-butylhydroquinone carnosic acid heat-responsive element xCT

DOI 10.1016/j.freeradbiomed.2013.11.002

PMID 24262357

发布时间 2013-12-30

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Free radical biology & medicine

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Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

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Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

Free radical biology & medicine

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Free radical biology & medicine

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