BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation.

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作者： Armen V,Gyulkhandanyan ^[1] ; Asuman,Mutlu ^[1] ; David J,Allen ^[1] ; John,Freedman ^[2] ; Valery,Leytin ^[3]

作者单位： Division of Transfusion Medicine, Department of Laboratory Medicine, The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada. ^[1] Division of Transfusion Medicine, Department of Laboratory Medicine, The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. ^[2] Division of Transfusion Medicine, Department of Laboratory Medicine, The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Physics, Ryerson University, Toronto, ON, Canada. Electronic address: leytinv@smh.ca. ^[3]