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Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

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第一作者： Maria Letícia de Castro,Barbosa

第一单位： Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro, P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil(1); Graduate Program of Chemistry (PGQu), Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

作者： Maria Letícia de Castro,Barbosa ^[1] ; Lídia Moreira,Lima ^[1] ; Roberta,Tesch ^[2] ; Carlos Mauricio R,Sant'Anna ^[3] ; Frank,Totzke ^[4] ; Michael H G,Kubbutat ^[4] ; Christoph,Schächtele ^[4] ; Stefan A,Laufer ^[5] ; Eliezer J,Barreiro ^[6]

作者单位： Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro, P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil(1); Graduate Program of Chemistry (PGQu), Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. ^[1] Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro, P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil(1). ^[2] Department of Chemistry, Federal Rural University of Rio de Janeiro (UFRRJ), Seropédica, RJ, Brazil. ^[3] ProQinase GmbH, Freiburg, Germany. ^[4] Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Eberhard-Karls-University Tübingen, Tübingen, Germany. ^[5] Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Federal University of Rio de Janeiro, P.O. Box 68024, 21944-971 Rio de Janeiro, RJ, Brazil(1); Graduate Program of Chemistry (PGQu), Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: ejbarreiro@ccsdecania.ufrj.br. ^[6]

关键词 Antitumor Cancer EGFR Quinazoline VEGFR-2

医学主题词抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);肿瘤(Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);喹唑啉类(Quinazolines);血管内皮生长因子受体2(Vascular Endothelial Growth Factor Receptor-2)

DOI 10.1016/j.ejmech.2013.10.058

PMID 24269511

发布时间 2018-12-03

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