The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment.

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作者： Chika,Iwamoto ^[1] ; Katsuto,Takenaka ^[1] ; Shingo,Urata ^[1] ; Takuji,Yamauchi ^[1] ; Takahiro,Shima ^[1] ; Takuro,Kuriyama ^[1] ; Shinya,Daitoku ^[1] ; Yasuyuki,Saito ^[2] ; Toshihiro,Miyamoto ^[1] ; Hiromi,Iwasaki ^[1] ; Issay,Kitabayashi ^[3] ; Katsuhiko,Itoh ^[4] ; Junji,Kishimoto ^[5] ; Daisuke,Kohda ^[6] ; Takashi,Matozaki ^[7] ; Koichi,Akashi ^[8]

作者单位： Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. ^[1] Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan. ^[2] Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan. ^[3] Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan. ^[4] Digital Medicine Initiative, Kyushu University, Fukuoka, Japan. ^[5] Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan. ^[6] Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. ^[7] Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. Electronic address: akashi@med.kyushu-u.ac.jp. ^[8]