2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.
作者:
主题词
3-羟邻氨苯甲酸3,4-双加氧酶(3-Hydroxyanthranilate 3,4-Dioxygenase);动物(Animals);脑(Brain);环氮氧化物(Cyclic N-Oxides);疾病模型, 动物(Disease Models, Animal);药物稳定性(Drug Stability);酶抑制剂(Enzyme Inhibitors);人类(Humans);神经变性疾病(Neurodegenerative Diseases);烟酸类(Nicotinic Acids);喹啉酸(Quinolinic Acid);大鼠(Rats)
DOI
10.1021/jm401249c
PMID
24274468
发布时间
2014-01-03
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