Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.

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第一作者： Douglas C,Dean

第一单位： Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, Rhode Island.

作者： Douglas C,Dean ^[1] ; Beth A,Jerskey ^[2] ; Kewei,Chen ^[3] ; Hillary,Protas ^[4] ; Pradeep,Thiyyagura ^[4] ; Auttawat,Roontiva ^[4] ; Jonathan,O'Muircheartaigh ^[5] ; Holly,Dirks ^[1] ; Nicole,Waskiewicz ^[1] ; Katie,Lehman ^[1] ; Ashley L,Siniard ^[6] ; Mari N,Turk ^[7] ; Xue,Hua ^[8] ; Sarah K,Madsen ^[8] ; Paul M,Thompson ^[8] ; Adam S,Fleisher ^[9] ; Matthew J,Huentelman ^[6] ; Sean C L,Deoni ^[1] ; Eric M,Reiman ^[10]

作者单位： Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, Rhode Island. ^[1] Alpert Medical School of Brown University, Providence, Rhode Island. ^[2] Banner Alzheimer's Institute, Phoenix, Arizona4Department of Mathematics, Arizona State University, Tempe5Department of Radiology, University of Arizona School of Medicine, Tucson6Arizona Alzheimer's Consortium, Phoenix. ^[3] Banner Alzheimer's Institute, Phoenix, Arizona6Arizona Alzheimer's Consortium, Phoenix. ^[4] Advanced Baby Imaging Lab, School of Engineering, Brown University, Providence, Rhode Island7Department of Neuroimaging, King's College London, Institute of Psychiatry, London, England. ^[5] Arizona Alzheimer's Consortium, Phoenix9Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona. ^[6] Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona. ^[7] Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles. ^[8] Banner Alzheimer's Institute, Phoenix, Arizona6Arizona Alzheimer's Consortium, Phoenix8Department of Neurology, University of California, San Diego School of Medicine, San Diego. ^[9] Banner Alzheimer's Institute, Phoenix, Arizona6Arizona Alzheimer's Consortium, Phoenix9Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona11Department of Psychiatry, University of Arizona School of Medicine, Phoenix. ^[10]

主题词发病年龄(Age of Onset);等位基因(Alleles);阿尔茨海默病(Alzheimer Disease);载脂蛋白E4(Apolipoprotein E4);大脑(Cerebrum);儿童, 学龄前(Child, Preschool);横断面研究(Cross-Sectional Studies);早期诊断(Early Diagnosis);疾病遗传易感性(Genetic Predisposition to Disease);遗传变异(Genetic Variation);杂合子(Heterozygote);人类(Humans);婴儿(Infant);磁共振成像(Magnetic Resonance Imaging)

DOI 10.1001/jamaneurol.2013.4544

PMID 24276092

发布时间 2022-03-17

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JAMA neurology

2014年71卷1期

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Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.

JAMA neurology

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Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.

JAMA neurology

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JAMA neurology

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