换一批A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.
第一作者：
Sabine M,Hölter
第一单位：
German Mouse Clinic, Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg/Munich, Germany.
作者：
医学主题词
等位基因(Alleles);动物(Animals);焦虑(Anxiety);自主神经系统(Autonomic Nervous System);行为, 动物(Behavior, Animal);心血管疾病(Cardiovascular Diseases);基因敲入技术(Gene Knock-In Techniques);葡萄糖(Glucose);杭廷顿病(Huntington Disease);学习(Learning);肺(Lung);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 神经学突变型(Mice, Neurologic Mutants);运动活动(Motor Activity);突变(Mutation);神经组织蛋白质类(Nerve Tissue Proteins);核蛋白质类(Nuclear Proteins);表型(Phenotype);旋转棒性能试验(Rotarod Performance Test);嗅觉(Smell);社会行为(Social Behavior);三核苷酸重复扩增(Trinucleotide Repeat Expansion)
DOI
10.1371/journal.pone.0080923
PMID
24278347
发布时间
2021-10-21
基金项目
R01 NS049206/NS/NINDS NIH HHS/United States
R01 NS073813/NS/NINDS NIH HHS/United States
R01NS049206/NS/NINDS NIH HHS/United States
R01NS073813/NS/NINDS NIH HHS/United States
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PloS one
e80923页
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