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首页> Regulatory toxicology and pharmacology : RTP> Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary.

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作者： Darrell R,Boverhof ^[1] ; Greg,Ladics ^[2] ; Bob,Luebke ^[3] ; Jane,Botham ^[4] ; Emanuela,Corsini ^[5] ; Ellen,Evans ^[6] ; Dori,Germolec ^[7] ; Michael,Holsapple ^[8] ; Scott E,Loveless ^[9] ; Haitian,Lu ^[10] ; Jan Willem,van der Laan ^[11] ; Kimber L,White ^[12] ; Yung,Yang ^[13]

作者单位： The Dow Chemical Company, Midland, MI, United States. Electronic address: rboverhof@dow.com. ^[1] DuPont Pioneer, Wilmington, DE, United States. ^[2] Cardiopulmonary and Immunotoxicology Branch, US Environmental Protection Agency, Research Triangle Park, NC, United States. ^[3] Syngenta Ltd., Macclesfield, UK. ^[4] Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy. ^[5] Pfizer, Inc., Groton, CT, United States. ^[6] National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States. ^[7] Battelle Memorial Institute, Columbus, OH, United States. ^[8] DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, United States. ^[9] Dow AgroSciences, Indianapolis, IN, United States. ^[10] Medicines Evaluation Board, Utrecht, The Netherlands. ^[11] ImmunoTox® Inc., Richmond, VA, United States. ^[12] Office of Pesticides Programs, US Environmental Protection Agency, Washington, DC, United States. ^[13]

关键词 2,4-D 2,4-dichlorophenoxyacetic acid ACD ACSA AFC CP CT DART DIT ELISA EOGRTS EPA EU Environmental chemicals European union FDA HESI ICH ILSI Immunotoxicity KLH LLNA NIEHS NIOSH NK NOAEL NRC NTP OECD PND RIVM SRBC STS T-cell dependent antibody reaction TDAR Testing US United States WoE agricultural chemical safety assessment allergic contact dermatitis antibody forming cell carbon tetrachloride cyclophosphamide developmental and reproductive toxicology developmental immunotoxicity dutch national institute of public health and the environment environmental protection agency enzyme linked immunosorbent assay extended one-generation reproductive toxicity study food and drug administration health and environmental sciences institute international conference on harmonization international life sciences institute keyhole limpet hemocyanin local lymph node assay national institute for occupational safety and health national institute of environmental health sciences national research council national toxicology program natural killer no observed adverse effect level organisation for economic cooperation and development postnatal day sheep red blood cells standard toxicology studies weight-of-evidence

主题词动物(Animals);环境暴露(Environmental Exposure);环境污染物(Environmental Pollutants);女(雌)性(Female);人类(Humans);免疫系统(Immune System);妊娠(Pregnancy);产前暴露迟发效应(Prenatal Exposure Delayed Effects);危险性评估(Risk Assessment);毒性试验(Toxicity Tests)

DOI 10.1016/j.yrtph.2013.11.012

PMID 24280359

发布时间 2014-01-13

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Regulatory toxicology and pharmacology : RTP

Regulatory toxicology and pharmacology

2014年68卷1期

96-107页

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