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首页> Nucleic acids research> megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

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作者： Sandrine,Boissel ^[1] ; Jordan,Jarjour ; Alexander,Astrakhan ; Andrew,Adey ; Agnès,Gouble ; Philippe,Duchateau ; Jay,Shendure ; Barry L,Stoddard ; Michael T,Certo ; David,Baker ; Andrew M,Scharenberg

作者单位： Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA, Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101, USA, Pregenen, Inc., Seattle, WA 98103, USA, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA, Cellectis S.A., Paris, 75013, France, Division of Basic Sciences, Fred Hutch Cancer Research Center, Seattle, WA 98109, USA, Department of Biochemistry, University of Washington, Seattle, WA 98195, USA, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA and Department of Immunology, University of Washington, Seattle, WA 98195, USA. ^[1]

主题词细胞, 培养的(Cells, Cultured);DNA裂解(DNA Cleavage);DNA结合蛋白质类(DNA-Binding Proteins);内切脱氧核糖核酸酶类(Endodeoxyribonucleases);基因敲除技术(Gene Knockout Techniques);基因, T细胞受体α(Genes, T-Cell Receptor alpha);遗传工程(Genetic Engineering);基因组学(Genomics);HEK293细胞(HEK293 Cells);人类(Humans);蛋白质结构, 三级(Protein Structure, Tertiary);重组融合蛋白质类(Recombinant Fusion Proteins)

DOI 10.1093/nar/gkt1224

PMID 24285304

发布时间 2024-05-19

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Nucleic acids research

Nucleic acids research

2014年42卷4期

2591-601页

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