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首页> Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association> Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin.

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin.

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作者： Jae Sue,Choi ^[1] ; Md Nurul,Islam ^[2] ; Md Yousof,Ali ^[2] ; Eon Ji,Kim ^[2] ; Young Myeong,Kim ^[3] ; Hyun Ah,Jung ^[4]

作者单位： Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: choijs@pknu.ac.kr. ^[1] Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea. ^[2] Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon 200-701, Republic of Korea. ^[3] Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: jungha@jbnu.ac.kr. ^[4]

关键词 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide 5,5′-dithiobis [2-nitrobenzoic acid]ACh AChE AD AGEs AMT APP AR ARI Alzheimer’s disease Apigenin derivative Aβ BACE1 BCh BChE COX-2 ChAT DMEM DTNB Diabetic complication Dulbecco’s Modified Eagle’s Medium EDTA FBS Flavonoid HRAR HRP Inflammation LPS MTT NADPH NO NOS PTP1B PVDF RLAR ROS acetylcholinesterase acetylthiocholine iodide advanced glycation endproducts aldose reductase aldose reductase inhibitor amyloid-β peptides butyrylcholinesterase butyrylthiocholine chloride choline acetyltransferase cyclooxygenase-2 ethylenediaminetetraacetic acid fetal bovine serum horseradish peroxidase human recombinant aldose reductase iNOS inducible nitric oxide synthase lipopolysaccharide nitric oxide nitric oxide synthase p-nitrophenyl phosphate pNPP polyvinylidene fluoride protein tyrosine phosphatase 1B rat lens aldose reductase reactive oxygen species β-nicotinamide adenine dinucleotide phosphate β-site amyloid precursor β-site amyloid precursor cleaving enzyme 1

主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);消炎药(Anti-Inflammatory Agents);芹菜素(Apigenin);细胞系(Cell Line);糖基化(Glycosylation);降血糖药(Hypoglycemic Agents);小鼠(Mice)

DOI 10.1016/j.fct.2013.11.020

PMID 24291393

发布时间 2014-01-20

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Food and chemical toxicology

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