换一批
第一作者：
J J,Rahn
第一单位：
Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.
作者：
关键词
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid2-benzamido-1,4-naphthoquinone2-propylpentane hydroxamic acid2h2j2q3nAEDATPATP metabolismDMEMDMSODulbecco’s Modified Eagle’s MediumECARETCFCCPHDACHEPESMBNINDSNQN1National Institute of Neurological Disorders and StrokeOCRPTZROSSAHASEMSOD2VKVK analog modified by the addition of a benzyl amine group to the 2′ position of the 1,4-naphthoquinone motif of VKVK analog. It is a modification of analog 2j with the addition of chlorine at the meta position of the added benzene ringVK analog. It is a modification of analog 2j, with the addition of a terminal alkyne to the added benzeneVK analog. It was created by replacing the central methylene group of analog 2j with a carbonyl groupVK3VPAVPHAVitamin KVitamin K3adenosine triphosphateanti-epileptic drugdays post fertilizationdimethyl sulfoxidedpfelectron transport chainepilepsyextracellular acidification ratehistone deacetylasemethylene bluemitochondriaoxygen consumption ratepentylenetetrazolreactive oxygen speciesrespirationstandard error of the meansuberoylanilide hydroxamic acidsuperoxide dismutasetrifluorocarbonylcyanide phenylhydrazonevalproic acid, 2-n-propylpentanoic acidzebrafish
医学主题词
腺苷三磷酸(Adenosine Triphosphate);动物(Animals);抗惊厥药(Anticonvulsants);细胞系(Cell Line);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物相互作用(Drug Interactions);酶抑制剂(Enzyme Inhibitors);癫痫(Epilepsy);小鼠(Mice);萘醌类(Naphthoquinones);氧耗量(Oxygen Consumption);戊四唑(Pentylenetetrazole);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);游泳(Swimming);时间因素(Time Factors);维生素K3(Vitamin K 3);斑马鱼(Zebrafish)
DOI
10.1016/j.neuroscience.2013.11.040
PMID
24291671
发布时间
2021-10-21
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Neuroscience
142-54页
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