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Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease.

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第一作者： Khoi D,Than

第一单位： Department of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.

作者： Khoi D,Than ^[1] ; Shayan U,Rahman ^[1] ; Lin,Wang ^[1] ; Adam,Khan ^[2] ; Kwaku A,Kyere ^[2] ; Tracey T,Than ^[1] ; Yoshinari,Miyata ^[1] ; Yoon-Shin,Park ^[3] ; Frank,La Marca ^[1] ; Hyungjin M,Kim ^[4] ; Huina,Zhang ^[1] ; Paul,Park ^[1] ; Chia-Ying,Lin ^[5]

作者单位： Department of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. ^[1] University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. ^[2] Department of Pharmaceutical Sciences, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. ^[3] Department of Biostatistics, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. ^[4] Department of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. Electronic address: lincy@umich.edu. ^[5]

关键词 BMP-2 Back pain Degenerative disc disease Discogenic back pain Rodent model Simvastatin