Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.
第一作者:
Eli,Shulman
第一单位:
From the Edith and Joseph Fischer Enzyme Inhibitors Laboratory, Schulich Faculty of Chemistry and.
作者:
医学主题词
氨基糖苷类(Aminoglycosides);动物(Animals);细胞凋亡(Apoptosis);耳蜗(Cochlea);细胞质(Cytoplasm);剂量效应关系, 药物(Dose-Response Relationship, Drug);遗传性疾病, 先天性(Genetic Diseases, Inborn);豚鼠(Guinea Pigs);人类(Humans);小鼠(Mice);线粒体(Mitochondria);线粒体蛋白质类(Mitochondrial Proteins);氧耗量(Oxygen Consumption);蛋白质生物合成(Protein Biosynthesis);蛋白质合成抑制药(Protein Synthesis Inhibitors);活性氧(Reactive Oxygen Species);核糖体(Ribosomes)
DOI
10.1074/jbc.M113.533588
PMID
24302717
发布时间
2021-10-21
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