HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.-论文-万方医学网

作者： Michal,Mielcarek ^[1] ; Christian,Landles ; Andreas,Weiss ; Amyaouch,Bradaia ; Tamara,Seredenina ; Linda,Inuabasi ; Georgina F,Osborne ; Kristian,Wadel ; Chrystelle,Touller ; Rachel,Butler ; Janette,Robertson ; Sophie A,Franklin ; Donna L,Smith ; Larry,Park ; Paul A,Marks ; Erich E,Wanker ; Eric N,Olson ; Ruth,Luthi-Carter ; Herman,van der Putten ; Vahri,Beaumont ; Gillian P,Bates

作者单位： Department of Medical and Molecular Genetics, King's College London, London, United Kingdom. ^[1]

主题词动物(Animals);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);大脑皮质(Cerebral Cortex);后成说, 遗传(Epigenesis, Genetic);女(雌)性(Female);基因敲低技术(Gene Knockdown Techniques);组蛋白脱乙酰基酶类(Histone Deacetylases);杭廷顿病(Huntington Disease);男(雄)性(Male);小鼠(Mice);小鼠, 129系(Mice, 129 Strain);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交CBA(Mice, Inbred CBA);小鼠, 基因敲除(Mice, Knockout);神经组织蛋白质类(Nerve Tissue Proteins);神经元(Neurons);核蛋白质类(Nuclear Proteins);表型(Phenotype);旋转棒性能试验(Rotarod Performance Test);突触传递(Synaptic Transmission);转录, 遗传(Transcription, Genetic)

DOI 10.1371/journal.pbio.1001717

PMID 24302884

发布时间 2021-10-21

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

PLoS biology

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

PLoS biology

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PLoS biology

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