换一批Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
第一作者：
Edward J,Hennessy
第一单位：
Oncology iMed, Innovative Medicines & Early Development, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
作者：
医学主题词
炔类(Alkynes);动物(Animals);抗肿瘤药(Antineoplastic Agents);仿生材料(Biomimetic Materials);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);二聚作用(Dimerization);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);凋亡抑制蛋白质类(Inhibitor of Apoptosis Proteins);小鼠(Mice);分子构象(Molecular Conformation);肿瘤(Neoplasms);寡肽类(Oligopeptides);构效关系(Structure-Activity Relationship);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/jm401075x
PMID
24320998
发布时间
2022-03-18
- 浏览124
Journal of medicinal chemistry
9897-919页
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