Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression.

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作者： Matthew J,Johnson ^[1] ; Niklas K,Björkström ^[2] ; Constantinos,Petrovas ^[3] ; Frank,Liang ^[4] ; Jason G D,Gall ^[5] ; Karin,Loré ^[4] ; Richard A,Koup ^[6]

作者单位： Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA. ^[1] Pathology Department, Center for Infectious Medicine, Karolinska Institutet, Stockholm 14186, Sweden; Department of Medicine, Karolinska Institutet, Stockholm 14186, Sweden. ^[2] Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ^[3] Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Pathology Department, Center for Infectious Medicine, Karolinska Institutet, Stockholm 14186, Sweden; Department of Medicine, Karolinska Institutet, Stockholm 14186, Sweden. ^[4] GenVec, Inc., Gaithersburg, MD 20878, USA. ^[5] Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: rkoup@mail.nih.gov. ^[6]

关键词 Adenovirus rAd28 rAd35