换一批Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands.
第一作者：
Katharina,Korpis
第一单位：
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, F.-L.-Jahn-Straße 17, 17487 Greifswald, Germany. Electronic address: korpis@uni-greifswald.de.
作者：
关键词
2′,7′-dichlorofluorescein diacetate3(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide3-MA3-methyladenine4,6-diamino-2-phenylindole4-difluoro-3,5-bis(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indaceneAIApoptosisAutophagyB(max)BODIPY 665/676 C(11)CancerDAPIDCFDADMSODTGDulbeccos phosphate buffered salineIC(50)K(d)K(i)LC3BLPOLipid peroxidationMMPMTTPARPPBSPIPI3KROSRPMI 8226 cellsSDSEMSigma-receptorTBHapoptosis inhibitordimethylsulfoxideditolylguanidinehalf maximal inhibitory drug concentrationinhibitory dissociation constantligand dissociation constantmaximal ligand binding sitesmicrotubule-associated protein light chain 3mitochondrial membrane potentialphosphatidylinositol 3-kinasepoly(ADP-ribose) polymerasepropidium iodidereactive oxygen speciesstandard deviationstandard error of meantertiary-butyl-hydroperoxidez-VAD-FMKz-Val-Ala-Asp(Ome)-CH(2)F
医学主题词
细胞凋亡(Apoptosis);自噬(Autophagy);细胞增殖(Cell Proliferation);人类(Humans);配体(Ligands);脂质过氧化作用(Lipid Peroxidation);多发性骨髓瘤(Multiple Myeloma);信号传导(Signal Transduction)
DOI
10.1016/j.bmc.2013.11.033
PMID
24331758
发布时间
2013-12-30
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