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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.

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第一作者： Yongqi,Deng

第一单位： Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA. Electronic address: yongqi.deng@merck.com.

作者： Yongqi,Deng ^[1] ; Gerald W,Shipps ^[2] ; Lianyun,Zhao ^[2] ; M Arshad,Siddiqui ^[2] ; Janeta,Popovici-Muller ^[2] ; Patrick J,Curran ^[2] ; Jose S,Duca ^[2] ; Alan W,Hruza ^[3] ; Thierry O,Fischmann ^[3] ; Vincent S,Madison ^[3] ; Rumin,Zhang ^[3] ; Charles W,McNemar ^[3] ; Todd W,Mayhood ^[3] ; Rosalinda,Syto ^[3] ; Allen,Annis ^[2] ; Paul,Kirschmeier ^[3] ; Emma M,Lees ^[4] ; David A,Parry ^[4] ; William T,Windsor ^[5]

作者单位： Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA. Electronic address: yongqi.deng@merck.com. ^[1] Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA. ^[2] Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ^[3] Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA. ^[4] Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: william.windsor@merck.com. ^[5]

关键词 CDK2 High throughput screening Kinases Modulator Tumor