Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus.
第一作者:
K,Sakata
第一单位:
Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: ksakata@uthsc.edu.
作者:
关键词
AdRBDNFBrain-derived neurotrophic factorCtDATDRD2DRD4EDTAEPSCFCFDRHIPIPSCKIVNETSESSRITHTPHWTadrenergic receptorcycle thresholddopamine D2 receptordopamine D4 receptordopamine transporterethylenediaminetetraacetic acidexcitatory postsynaptic currentfalse discovery ratefrontal cortexgene expressionhippocampusinhibitory postsynaptic currentknock-in promoter IVmonoamine systemsnorepinephrine transporterpromoter IVqRT-PCRquantitative reverse-transcription polymerase chain reactionselective serotonin reuptake inhibitorstandard error of meantryptophan hydroxylasetyrosine hydroxylasewild-type
医学主题词
动物(Animals);生物源单胺类(Biogenic Monoamines);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);女(雌)性(Female);额叶(Frontal Lobe);海马(Hippocampus);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 突变型(Mice, Mutant Strains);启动区, 遗传(Promoter Regions, Genetic)
DOI
10.1016/j.neuroscience.2013.12.013
PMID
24345476
发布时间
2014-02-03
- 浏览23
Neuroscience
265-75页
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