The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs.

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作者： Emily R,Jackson ^[1] ; Géraldine,San Jose ^[1] ; Robert C,Brothers ^[1] ; Emma K,Edelstein ^[1] ; Zachary,Sheldon ^[1] ; Amanda,Haymond ^[2] ; Chinchu,Johny ^[2] ; Helena I,Boshoff ^[3] ; Robin D,Couch ^[2] ; Cynthia S,Dowd ^[4]

作者单位： Department of Chemistry, George Washington University, 725 21st Street NW, Corcoran 107, Washington, DC 20052, United States. ^[1] Department of Chemistry and Biochemistry and the National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, United States. ^[2] Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States. ^[3] Department of Chemistry, George Washington University, 725 21st Street NW, Corcoran 107, Washington, DC 20052, United States. Electronic address: cdowd@gwu.edu. ^[4]

关键词 Antibiotic Dxr Mycobacterium tuberculosis Nonmevalonate pathway

主题词抗结核药(Antitubercular Agents);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);磷霉素(Fosfomycin);微生物敏感性试验(Microbial Sensitivity Tests);结核分枝杆菌(Mycobacterium tuberculosis);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2013.11.067

PMID 24360562

发布时间 2021-10-21

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