Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation.

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作者： Xinlong,Luo ^[1] ; Beibei,Wang ^[2] ; Fan,Tang ^[1] ; Junmei,Zhang ^[3] ; Yingming,Zhao ^[3] ; Hui,Li ^[4] ; Ying,Jin ^[5]

作者单位： Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ^[1] Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ^[2] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[3] Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: biolihui@163.com. ^[4] Shanghai Stem Cell Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: yjin@sibs.ac.cn. ^[5]

关键词 Protein stability SRG3 SWI/SNF-like BAF complex Ubiquitination Wwp2