换一批
换一批Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors.
作者：
关键词
2-[(18)F]FA2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine5-[(123)I]-5-iodo-3-(2(S)-azetidinylmethoxy)pyridine5-[(123)I]IAADAlzheimers’s diseaseAlzheimers’s disease (AD)FlubatineFluorine-18HPLCNicotinic acetylcholine receptor (nAChR)PETPSL/mm(2)ROIhigh performance liquid chromatographynAChRnicotinic acetylcholine receptorp.s.particle sizephotostimulated luminescence per areapositron emission tomographyregions of interest
主题词
动物(Animals);苯甲酰胺类(Benzamides);脑(Brain);结晶学, X线(Crystallography, X-Ray);女(雌)性(Female);氟放射性同位素(Fluorine Radioisotopes);人类(Humans);动力学(Kinetics);男(雄)性(Male);模型, 分子(Models, Molecular);分子结构(Molecular Structure);放射性核素显像(Radionuclide Imaging);放射性药物(Radiopharmaceuticals);大鼠(Rats);受体, 烟碱(Receptors, Nicotinic);立体异构现象(Stereoisomerism);猪(Swine)
DOI
10.1016/j.bmc.2013.12.011
PMID
24369841
发布时间
2016-11-25
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